Our paper ‘Thalamic reticular nucleus induces fast and local modulation of arousal state’ just went online at eLife.
In this study we found that optogenetic drive of TRN induces slow waves in associated regions of neocortex, similar to the local sleep observed in sleep deprived animals. The manipulation also very rapidly modulated the arousal state of mice, reducing muscle tone and propensity to move around. Our results indicate that thalamic inhibition via TRN can serve as a mechanism for rapid and local modulation of cortical arousal state.
Get the paper at eLife:
Laura D Lewis, Jakob Voigts, Francisco J Flores, Lukas I Schmitt, Matthew A Wilson, Michael M Halassa, Emery N Brown: Thalamic reticular nucleus induces fast and local modulation of arousal state